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bama - High Dimensional Bayesian Mediation Analysis

Perform mediation analysis in the presence of high-dimensional mediators based on the potential outcome framework. Bayesian Mediation Analysis (BAMA), developed by Song et al (2019) <doi:10.1111/biom.13189> and Song et al (2020) <arXiv:2009.11409>, relies on two Bayesian sparse linear mixed models to simultaneously analyze a relatively large number of mediators for a continuous exposure and outcome assuming a small number of mediators are truly active. This sparsity assumption also allows the extension of univariate mediator analysis by casting the identification of active mediators as a variable selection problem and applying Bayesian methods with continuous shrinkage priors on the effects.

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cpp

4.35 score 45 scripts 378 downloads

SynDI - Synthetic Data Integration

Regression inference for multiple populations by integrating summary-level data using stacked imputations. Gu, T., Taylor, J.M.G. and Mukherjee, B. (2021) A synthetic data integration framework to leverage external summary-level information from heterogeneous populations <arXiv:2106.06835>.

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4.30 score 2 stars 7 scripts 193 downloads

AEenrich - Adverse Event Enrichment Tests

We extend existing gene enrichment tests to perform adverse event enrichment analysis. Unlike the continuous gene expression data, adverse event data are counts. Therefore, adverse event data has many zeros and ties. We propose two enrichment tests. One is a modified Fisher's exact test based on pre-selected significant adverse events, while the other is based on a modified Kolmogorov-Smirnov statistic. We add Covariate adjustment to improve the analysis."Adverse event enrichment tests using VAERS" Shuoran Li, Lili Zhao (2020) <doi:10.48550/arXiv.2007.02266>.

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3.95 score 3 stars 3 scripts 276 downloads

snSMART - Small N Sequential Multiple Assignment Randomized Trial Methods

Consolidated data simulation, sample size calculation and analysis functions for several snSMART (small sample sequential, multiple assignment, randomized trial) designs under one library. See Wei, B., Braun, T.M., Tamura, R.N. and Kidwell, K.M. "A Bayesian analysis of small n sequential multiple assignment randomized trials (snSMARTs)." (2018) Statistics in medicine, 37(26), pp.3723-3732 <doi:10.1002/sim.7900>.

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bayesian-analysisclinical-trialsrare-diseasesmall-samplejagscpp

3.30 score 2 stars 3 scripts 159 downloads

PPMR - Probabilistic Two Sample Mendelian Randomization

Efficient statistical inference of two-sample MR (Mendelian Randomization) analysis. It can account for the correlated instruments and the horizontal pleiotropy, and can provide the accurate estimates of both causal effect and horizontal pleiotropy effect as well as the two corresponding p-values. There are two main functions in the 'PPMR' package. One is PMR_individual() for individual level data, the other is PMR_summary() for summary data.

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openblascppopenmp

3.30 score 2 stars 20 scripts 199 downloads

StackImpute - Tools for Analysis of Stacked Multiple Imputations

Provides methods for inference using stacked multiple imputations augmented with weights. The vignette provides example R code for implementation in general multiple imputation settings. For additional details about the estimation algorithm, we refer the reader to Beesley, Lauren J and Taylor, Jeremy M G (2020) “A stacked approach for chained equations multiple imputation incorporating the substantive model” <doi:10.1111/biom.13372>, and Beesley, Lauren J and Taylor, Jeremy M G (2021) “Accounting for not-at-random missingness through imputation stacking” <arXiv:2101.07954>.

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3.18 score 1 dependents 7 scripts 233 downloads

qif - Quadratic Inference Function

Developed to perform the estimation and inference for regression coefficient parameters in longitudinal marginal models using the method of quadratic inference functions. Like generalized estimating equations, this method is also a quasi-likelihood inference method. It has been showed that the method gives consistent estimators of the regression coefficients even if the correlation structure is misspecified, and it is more efficient than GEE when the correlation structure is misspecified. Based on Qu, A., Lindsay, B.G. and Li, B. (2000) <doi:10.1093/biomet/87.4.823>.

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openblas

3.18 score 1 dependents 2 scripts 150 downloads

messi - Mediation with External Summary Statistic Information

Fits the MESSI, hard constraint, and unconstrained models in Boss et al. (2023) <doi:10.48550/arXiv.2306.17347> for mediation analyses with external summary-level information on the total effect.

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2.70 score 2 scripts 185 downloads

medScan - Large Scale Single Mediator Hypothesis Testing

A collection of methods for large scale single mediator hypothesis testing. The six included methods for testing the mediation effect are Sobel's test, Max P test, joint significance test under the composite null hypothesis, high dimensional mediation testing, divide-aggregate composite null test, and Sobel's test under the composite null hypothesis. Du et al (2023) <doi:10.1002/gepi.22510>.

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2.70 score 5 scripts 175 downloads

gigg - Group Inverse-Gamma Gamma Shrinkage for Sparse Regression with Grouping Structure

A Gibbs sampler corresponding to a Group Inverse-Gamma Gamma (GIGG) regression model with adjustment covariates. Hyperparameters in the GIGG prior specification can either be fixed by the user or can be estimated via Marginal Maximum Likelihood Estimation. Jonathan Boss, Jyotishka Datta, Xin Wang, Sung Kyun Park, Jian Kang, Bhramar Mukherjee (2021) <arXiv:2102.10670>.

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openblascpp

2.70 score 2 scripts 207 downloads

MetaIntegration - Ensemble Meta-Inference Framework

An ensemble meta-inference framework to integrate multiple regression models into a current study. Gu, T., Taylor, J.M.G. and Mukherjee, B. (2021) <arXiv:2010.09971>. A meta-analysis framework along with two weighted estimators as the ensemble of empirical Bayes estimators, which combines the estimates from the different external models. The proposed framework is flexible and robust in the ways that (i) it is capable of incorporating external models that use a slightly different set of covariates; (ii) it is able to identify the most relevant external information and diminish the influence of information that is less compatible with the internal data; and (iii) it nicely balances the bias-variance trade-off while preserving the most efficiency gain. The proposed estimators are more efficient than the naive analysis of the internal data and other naive combinations of external estimators.

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2.70 score 1 stars 1 scripts 207 downloads

FEprovideR - Fixed Effects Logistic Model with High-Dimensional Parameters

A structured profile likelihood algorithm for the logistic fixed effects model and an approximate expectation maximization (EM) algorithm for the logistic mixed effects model. Based on He, K., Kalbfleisch, J.D., Li, Y. and Li, Y. (2013) <doi:10.1007/s10985-013-9264-6>.

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2.70 score 1 stars 1 scripts 145 downloads

INTRIGUE - Quantify and Control Reproducibility in High-Throughput Experiments

Estimate the proportions of the null and the reproducibility and non-reproducibility of the signal group for the input data set. The Bayes factor calculation and EM (Expectation Maximization) algorithm procedures are also included.

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2.48 score 2 scripts 139 downloads

hlt - Higher-Order Item Response Theory

Higher-order latent trait theory (item response theory). We implement the generalized partial credit model with a second-order latent trait structure. Latent regression can be done on the second-order latent trait. For a pre-print of the methods, see, "Latent Regression in Higher-Order Item Response Theory with the R Package hlt" <https://mkleinsa.github.io/doc/hlt_proof_draft_brmic.pdf>.

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cpp

1.70 score 6 scripts 425 downloads